Liquid water is a requirement for life on Earth. But in other, much colder worlds where water is a solid, life might exist beyond the bounds of water-based chemistry. Cornell University chemical engineers and astronomers have offered a template for life that could thrive in a harsh, cold world like Titan - the giant moon of Saturn. A planetary body awash with seas not of water, but of liquid methane at temperatures of 292 degrees below zero, could harbor methane-based, oxygen-free cells that metabolize, reproduce, and do everything life on Earth does -- except it would be "Life Not as We Know It."